J Marc Simard Selected Research

Hemorrhagic Stroke

3/2015	Glibenclamide for the treatment of ischemic and hemorrhagic stroke.
10/2013	Glibenclamide for the treatment of acute CNS injury.

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J Marc Simard Research Topics

Disease

40	Brain Edema (Cerebral Edema) 11/2023 - 04/2006
36	Edema (Dropsy) 01/2023 - 01/2004
28	Stroke (Strokes) 11/2023 - 01/2003
22	Traumatic Brain Injuries (Traumatic Brain Injury) 11/2023 - 02/2008
19	Hemorrhage 10/2023 - 12/2008
19	Subarachnoid Hemorrhage (Aneurysmal Subarachnoid Hemorrhage) 07/2023 - 02/2009
18	Infarction (Infarctions) 11/2023 - 04/2006
17	Ischemic Stroke 01/2023 - 12/2002
17	Ischemia 01/2020 - 01/2004
14	Brain Ischemia (Cerebral Ischemia) 01/2023 - 01/2011
13	Wounds and Injuries (Trauma) 12/2022 - 02/2008
13	Spinal Cord Injuries (Spinal Cord Injury) 06/2022 - 08/2007
9	Neuroinflammatory Diseases 08/2023 - 07/2012
9	Brain Injuries (Brain Injury) 07/2022 - 06/2003
8	Inflammation (Inflammations) 01/2024 - 02/2009
8	Necrosis 12/2021 - 08/2007
8	Hypoxia (Hypoxemia) 05/2015 - 01/2004
7	Brain Contusion 10/2023 - 12/2009
6	Contusions 10/2023 - 02/2012
6	Pain (Aches) 07/2023 - 01/2019
6	Spinal Injuries (Spinal Injury) 12/2022 - 01/2017
6	Hypertension (High Blood Pressure) 12/2013 - 01/2003
4	Cytokine Release Syndrome 01/2024 - 01/2021
4	Type 2 Diabetes Mellitus (MODY) 01/2023 - 10/2013
4	Hypothermia 06/2022 - 11/2015
4	Cerebral Infarction 01/2021 - 01/2011
4	Brain Neoplasms (Brain Tumor) 12/2017 - 10/2013
4	Brain Diseases (Brain Disorder) 05/2015 - 12/2011
3	COVID-19 01/2024 - 01/2021
3	Infections 01/2024 - 12/2020
3	Gliosis 08/2023 - 09/2017
3	Headache (Headaches) 07/2023 - 12/2021
3	Hydrocephalus (Hydrocephaly) 01/2023 - 08/2017
3	Experimental Autoimmune Encephalomyelitis (Encephalomyelitis, Autoimmune Experimental) 01/2023 - 11/2015
3	Aneurysm (Aneurysms) 01/2023 - 12/2013
3	Heart Arrest (Cardiac Arrest) 01/2018 - 10/2011
3	Neoplasms (Cancer) 01/2018 - 12/2013
3	Middle Cerebral Artery Infarction (Middle Cerebral Artery Syndrome) 08/2015 - 02/2009
2	Intractable Pain 07/2023 - 11/2021
2	Shock 01/2023 - 07/2014
2	Acute Pain 12/2021 - 11/2021
2	Neurocognitive Disorders (Clerambault Syndrome) 10/2021 - 01/2021
2	Neuralgia (Stump Neuralgia) 01/2021 - 01/2019
2	Venous Thrombosis (Deep-Vein Thrombosis) 01/2021 - 12/2013
2	Thrombocytopenia (Thrombopenia) 01/2021 - 12/2013
2	Intracranial Hypertension 01/2019 - 10/2015
2	Glioma (Gliomas) 01/2018 - 01/2017

Drug/Important Bio-Agent (IBA)

48	Glyburide (Glibenclamide)FDA LinkGeneric 10/2023 - 04/2006
28	Sulfonylurea ReceptorsIBA 10/2023 - 04/2006
22	Adenosine Triphosphate (ATP)IBA 01/2023 - 01/2004
20	Proteins (Proteins, Gene)FDA Link 01/2024 - 01/2006
8	CationsIBA 01/2023 - 01/2004
8	Heparin (Liquaemin)FDA LinkGeneric 01/2021 - 12/2010
7	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 01/2021 - 02/2009
5	CytokinesIBA 01/2024 - 01/2020
5	Biomarkers (Surrogate Marker)IBA 01/2022 - 06/2006
5	Ion Channels (Ion Channel)IBA 01/2020 - 08/2009
4	Interleukin-6 (Interleukin 6)IBA 11/2023 - 01/2021
4	Opioid Analgesics (Opioids)IBA 07/2023 - 11/2021
4	Aquaporins (Water Channels)IBA 01/2023 - 02/2015
4	Explosive Agents (Explosives)IBA 08/2019 - 10/2011
4	Matrix Metalloproteinase 9 (Gelatinase B)IBA 12/2018 - 09/2012
4	Tissue Plasminogen Activator (Alteplase)FDA Link 01/2018 - 09/2012
4	Immunoglobulin G (IgG)IBA 08/2015 - 02/2009
3	Glial Fibrillary Acidic ProteinIBA 08/2023 - 10/2008
3	Aquaporin 4IBA 08/2023 - 09/2015
3	Analgesics (Analgesic Drugs)IBA 07/2023 - 11/2021
3	Toll-Like Receptor 4IBA 12/2020 - 03/2015
3	OligodeoxyribonucleotidesIBA 01/2020 - 04/2010
3	Caspase 3 (Caspase-3)IBA 07/2012 - 02/2009
3	Angiotensin IIIBA 01/2006 - 01/2003
2	Antiviral Agents (Antivirals)IBA 01/2024 - 01/2021
2	InflammasomesIBA 01/2024 - 01/2022
2	IodineIBA 11/2023 - 01/2019
2	vpr Gene ProductsIBA 08/2023 - 12/2020
2	LipopolysaccharidesIBA 01/2023 - 01/2017
2	Glucose (Dextrose)FDA LinkGeneric 01/2023 - 01/2022
2	Betulinic AcidIBA 10/2022 - 01/2019
2	AntioxidantsIBA 10/2022 - 01/2019
2	ChemokinesIBA 01/2022 - 01/2021
2	HMGB1 Protein (HMG1)IBA 01/2022 - 01/2020
2	6,7-dihydroxyflavoneIBA 10/2021 - 01/2021
2	NF-kappa B (NF-kB)IBA 01/2021 - 07/2012
2	Chemokine CCL2 (Monocyte Chemoattractant Protein 1)IBA 01/2021 - 09/2017
2	Nitric Oxide Synthase Type II (Inducible Nitric Oxide Synthase)IBA 01/2020 - 01/2016
2	LigandsIBA 01/2020 - 03/2015
2	Transient Receptor Potential ChannelsIBA 01/2019 - 08/2007
2	ElementsIBA 10/2018 - 04/2014
2	Nitric Oxide Synthase (NO Synthase)IBA 09/2017 - 01/2016
2	Riluzole FDA LinkGeneric 11/2015 - 01/2012

Therapy/Procedure

21	Therapeutics 07/2023 - 12/2010
10	Decompressive Craniectomy 01/2022 - 05/2009
7	Decompression 12/2022 - 01/2013
4	Surgical Decompression 12/2022 - 09/2012
4	Craniotomy 11/2021 - 12/2009
3	Drug Therapy (Chemotherapy) 07/2022 - 01/2016
3	Cardiopulmonary Resuscitation (CPR) 01/2018 - 10/2011
2	Analgesia 07/2023 - 07/2022
2	Intravenous Administration 10/2022 - 01/2019
2	Minimally Invasive Surgical Procedures 09/2019 - 02/2016